2023-05-16 06:40Press release

New SmiLe company develops first effective treatment for hypothyroidism

Sahil Gupta, the CEO of Prolevi BioSahil Gupta, the CEO of Prolevi Bio


Lund, Sweden – Prolevi Bio's unique technology is intended to help those 10-20 percent who don't respond to today's medicine for underactive thyroid glands. The company develops a modified release thyroid hormone tablet formulation, mimicking the natural hormone release cycles. In addition, the treatment will be tailored according to each patient's needs using Prolevi Bio's mathematical models.


Globally, 750 million patients, mainly women, suffer from hypothyroidism, i.e. an underactive thyroid. However, as many as 600M patients treated with current medication are dissatisfied with the treatment, and 150M patients do not respond to the drugs at all. Current treatments are unable to follow healthy thyroid gland release cycles.


Prolevi Bio develops a platform technology that releases the hormone according to the body's circadian rhythm. In addition, the drug will act as a precision medicine – each patient will receive an individually adapted treatment for optimal effect – with the help of the company's mathematical models that account for patient’s physiological and physical parameters. The technology can also be used for other applications.


The company has opened a financing seed round and aims to raise another 5-6 million euros (Series A Tr.1), to finance a phase 1 study validating the company's innovation with fast-track market authorization in selected EU countries under accelerated regulatory approval pathway.


“Going forward, we will develop increasingly sophisticated mathematical models to get even better treatment at the individual level and further strengthen our IP portfolio. We are happy that, as an incubator company, we receive support and help from experienced SmiLe coaches when it comes to capital acquisition and critical operational decisions”, says Sahil Gupta, CEO of Prolevi Bio.


“We are thrilled to support the commercialization of Prolevi Bio's medicines, developed for an area with high unmet needs. In addition to receiving our broad business development support, our new startups join a community of previous and current portfolio companies. Here is a vast collective experience, which contributes to accelerating the companies´ development”, says Lina Olsen Boreson, COO at SmiLe.


For more information, please contact:

Prolevi Bio AB

Sahil Gupta, CEO at Prolevi Bio, sg@prolevi.bio, +49 152 0535 9402



SmiLe Incubator AB

Lina Olsen Boreson, COO at SmiLe, lina@smileincubator.life, +46 (0)703-781279

Language: English

About SmiLe Venture Hub – Pioneering Life Science Innovations

About SmiLe Incubator SmiLe Incubator is a life science business incubator based in Medicon Village in Lund, Sweden. SmiLe offers business coaching, a broad international industry and investor network and a unique laboratory infrastructure with state-of-the art instrumentation. Since the start, SmiLe has helped 100+ entrepreneurs commercialize their business ideas. Currently there are some 30 companies in SmiLe incubator which, together with alumni companies, have attracted more than EUR 717 million in venture capital since 2014. To date, 21 of SmiLe´s companies have launched an IPO and these listed companies have a market capitalization of more than EUR 500 million (Q4 2022). SmiLe is a non-profit organization and receives basic funding from Region Skåne, Lund Municipality, Lund University and Medicon Village. SmiLe´s sponsors are Agilent, Sparbanken Skåne, Awa, Høiberg, Magle Chemoswed, Merck, Prevas, Setterwalls, Zacco, Phase Holographic Imaging and ChemoMetec. www.smileincubator.life